polC [2017-12-07 13:12:25]

DNA polymerase III, leading strand polymerase (alpha subunit), part of the replisome

locus: BSU16580

pI: 5.14

mw: 162.42 kDa

protein length: 1437 aa

gene length: 4311 bp

function: DNA replication

product: DNA polymerase III (alpha subunit)

essential: yes

ec: 2.7.7.7

synonyms: mutI,dnaF,dnaP

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 1,727,133 → 1,731,446

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)
• required for bacteriophage SPP1 replication [Pubmed|23268446]

Protein family

• PolC subfamily (according to Swiss-Prot)

Structure

• [PDB|3F2B] (from ''Geobacillus kaustophilus'', 71% identity) [Pubmed|19106298]

[SW|Localization]

• forms foci [Pubmed|21958350]
• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
  description: [Pubmed|22383849]

• genes: [gene|4A637EB9B400D30E5C6246D1E0EB5E6A30F38A16|uppS]-[gene|7E7F6BBA03C443A5AFA05A6D9352FEF1212A5AF6|cdsA]-[gene|58CDF08A8F05C0BC25EB6E400316F85FD0F307E5|ispC]-[gene|CB50289535EA537F63BADD459BD11AA7759A6658|rasP]-[gene|848570563D3C92A8E1E6AB4DA530388D8AE94E75|proS]-[gene|FB97DF0C147FB29944F60214CB9BC1803861DAA0|polC]
  description: [Pubmed|22383849]

References

Reviews

• 19106294,28073967

Original publications

• 15186423,20122408,11721055,23563155,23268446,21740522,21958350,24062730,24106089,19106298,28002733,28575448,28878042